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MRCP Q 885

Anti-Ro antibodies in isolation (negative ANA) occur in which of the following conditions?

1. Sj÷gren’s syndrome
2. Sicca syndrome
3. Systemic lupus erythematosus (SLE)
4. Scleroderma
5. Polymyositis

Correct Answer 3

Systemic lupus erythematosus (SLE) ANA-negative lupus is uncommon. ANAnegative SLE patients are usually Ro-positive and have skin rashes with or without photosensitivity. In Sjögren’s syndrome, Ro and La antibodies commonly coexist. Sicca syndrome is not typically associated with autoantibodies.

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