Anti-Ro antibodies in isolation (negative ANA) occur in which of the following conditions?
1. Sj÷gren’s syndrome
2. Sicca syndrome
3. Systemic lupus erythematosus (SLE)
Correct Answer 3
Systemic lupus erythematosus (SLE) ANA-negative lupus is uncommon. ANAnegative SLE patients are usually Ro-positive and have skin rashes with or without photosensitivity. In Sjögren’s syndrome, Ro and La antibodies commonly coexist. Sicca syndrome is not typically associated with autoantibodies.