An elderly woman with poorly controlled blood glucose levels

An elderly woman with type 2 diabetes has poorly controlled blood glucose levels despite treatment with metformin. The physician decides to try pioglitazone.

Which best describes the mode of action of pioglitazone?

a) reduces insulin resistance and improves insulin sensitivity

b) suppresses basal hepatic glucose production

c) reduces fasting plasma glucose

d) activates the AMP-activated protein kinase

e) stimulates first-phase insulin secretion in the pancreatic beta cells 


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