Breakdown of tissue cells release protein
Capillary walls are more permeable
Increased blood flow transports more protein into the area
Intracapillary pressure is raised
Plasma cells release gamma globulin
The increased permeability allows the exudation of plasma proteins.
Inflammation is the reaction of the tissue elements to injury. Vascular changes occur, resulting in the generation of a protein rich exudate. So long as the injury does not totally destroy the existing tissue architecture, the episode may resolve with restoration of original tissue architecture.
- Vasodilation occurs and persists throughout the inflammatory phase.
- Inflammatory cells exit the circulation at the site of injury.
- The equilibrium that balances Starlings forces within capillary beds is disrupted and a protein rich exudate will form as the vessel walls also become more permeable to proteins.
- The high fibrinogen content of the fluid may form a fibrin clot. This has several important immunomodulatory functions.
Progression to chronic inflammation
- Microbacterial infections e.g. Viruses, exotoxins or endotoxins released by bacteria
- Chemical agents
- Physical agents e.g. Trauma
- Hypersensitivity reactions
- Tissue necrosis
Presence of neutrophil polymorphs is a histological diagnostic feature of acute inflammation