UKMLA PLAB AMC USMLE Prometric MCQ

Correct Answer: B

Explanation:
Loop and thiazide diuretics decrease potassium and magnesium levels, predisposing patients taking both a diuretic and digoxin to an increased risk of digoxin toxicity. Also, amphotericin B (Fungizone), an antifungal, has an additive potassium-lowering effect when given with a thiazide or loop diuretic. Thiazides may increase the blood levels of lithium. Bile acid sequestrants cholestyramine (Questran) and colestipol (Colestid) decrease the absorption of thiazide diuretics when given concomitantly, while nonsteroidal anti-inflammatory drugs such as indomethacin (Indocin) may decrease the therapeutic effects of both the loop and thiazide diuretics