 Correct Answer: E Explanation: The Reed-Sternberg cell is pathognemonic for Hodgkin's disease. The Reed-Sternberg cell has a multi-lobed nucleus with is a large 'owl eye' nucleoli.Smudge cells (choice a) are cells that have been destroyed during the slide preparation. They are seen in acute leukemias.The Philadelphia chromosome (choice b) is a translocation between chromosomes 22 and 9, is positive in the vast majority (90-95%) of patients with chronic myelogenous leukemia.Sezary cell (choice c) is an atypical lymphoid cells seen in Sezary syndrome and mycosis fungoides. Bence Jones protein (choice d) is L chains seen with multiple myeloma. |
Labels: USMLE Step 2 MCQ Answers
