Answer:USMLE step 2 Mcq 49:A 25 year old male presents with an enlarged, painless swelling in his neck


Correct Answer: E
The Reed-Sternberg cell is pathognemonic for Hodgkin's disease. The Reed-Sternberg cell has a multi-lobed nucleus with is a large 'owl eye' nucleoli.Smudge cells (choice a) are cells that have been destroyed during the slide preparation. They are seen in acute leukemias.The Philadelphia chromosome (choice b) is a translocation between chromosomes 22 and 9, is positive in the vast majority (90-95%) of patients with chronic myelogenous leukemia.Sezary cell (choice c) is an atypical lymphoid cells seen in Sezary syndrome and mycosis fungoides. Bence Jones protein (choice d) is L chains seen with multiple myeloma.


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